Make rolling better.
Rollkit is a combination of natural supplements that has been shown to have positive effects with MDMA use in research studies.
Like the ALCAR/ALA pair, co-enzyme Q10 (CoQ10) acts to prevent peroxidation of fatty acid chains, but tends to concentrate in the heart/liver/kidneys rather than the brain. It also works to manage calcium channels (like magnesium bis-glycinate below) where it resides and recycles vitamin E (also below), so that both the vitamin E in your RollKit and your dietary vitamin E are “in use” for longer and hence more effective.
Alpha Lipoic Acid
Alpha-lipoic acid (ALA) combines with acetyl l-carnitine (above) to prevent MDMA toxicity in the brain. Together, these two substances are astonishingly effective in interrupting the processes of glutamate toxicity: promoting endogenous antioxidant enzymes and, this one is key, transferring and breaking down fatty acid molecules. This prevents the formation of reactive oxygen species, or ROS and in turn prevents any that slip through from “stealing” electrons from more fatty acids.
Green Tea Extract
Acetyl L Carnite
Acetyl L-Carnitine (ALCAR) synergises incredibly effectively with alpha-lipoic acid (below), working to remove the “fuel” for toxic oxidisation in the brain – these two substances can easily cross the blood-brain barrier, meaning that they can target oxidisation happening there while others, like vitamin C, will concentrate elsewhere.
Like acai berry, ginger is loaded with dozens of beneficial chemicals ranging from antioxidants to anti-inflammatories and antidepressants which can prove beneficial when fighting off oxidative stress and even the psychological effects of a comedown. As an added benefit for those of you who get queasy on the come-up, ginger is renowned for its ability to combat nausea (usually intended for when you’re ill, but it does the trick on a rough come-up too)..
One of the ways that the stimulant effects of MDMA work is by the opening of ion channels which flood calcium into the neuron. However, all this calcium interferes with the working of the neuron; magnesium blocks this channel to moderate the calcium influx and mitigate the harm caused. The bis-glycinate salt (a mix of magnesium and glycine) is among the most bioavailable forms of magnesium, meaning that the magnesium is absorbed into the body effectively.
Vitamin C works to enhance the overall antioxidant effect. In addition to scavenging reactive oxygen species in broadly the same manner as EGCG, donating a hydroxyl group to reduce the oxygen atom to a water molecule, vitamin C assists in the recycling of vitamin E to enhance its effects.
The research behind it
Numerous studies have been done using the same natural supplements in our kit, and below we have listed them for you to read through and gain a better understanding of the mechanisms and the role supplements can play in safety with MDMA use.